The Pantothenic Acid Requirement of Chicks

The influence of microorganisms and of stress on the chick's requirement for pantothenic acid.

1. The responses of germ-free (GF) and conventional (CV) chicks to suboptimal amounts of dietary calcium pantothenate (CaPa) were compared. At the lower levels of supplementation the signs of deficiency were more severe in the CV chicks. 2. Calculations based on mean body-weights of chicks given graded dietary supplements of calcium pantothenate (CaPa) in both environments showed that, to achie...

The metabolism of pantothenic acid.

The formulation of this pathway was based on: (a) the finding that cysteine supplies the sulfur-containing moiety of CoA (3,4); (b) the activities of pantetheine and pantothenylcysteine as growth factors for Acetobacter suboxydans (4-6) and Lactobacillus helveticus (7); (c) the presence of enzymes in these two organisms and also in Lactobacillus bulgur&s which decarboxylate pantothenylcysteine ...

Microbic Decomposition of Pantothenic Acid.

The Liberation of Pantothenic Acid from Coenzyme

It was reported previously that coenzyme A contained pantothenic acid bound in such a manner as to make it unavailable in microbiological tests (1). A liberation of p;alanine on acid hydrolysis indicated early the presence of pantothenic acid, which was confirmed by chick assay (2). While the chick assay for pantothenic acid and the p-alanine assay by the yeast growth test yielded equivalent am...

The effect of pantothenic acid dosage and environmental temperature and humidity upon the dermal and renal excretion of pantothenic acid.

The loss of considerable amounts of water-soluble nutrients in the sweat would have an important bearing on nutrition in the tropics and in hot humid seasons of the year in the temperate zone, provided these losses represented something more than a mere diversion of excretion from kidney to sweat glands. The possibility of such losses has stimulated considerable research in recent years, partic...